2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118455
    MRS1097 185259-16-9 98%
    MRS1097 is a potent antagonist of adenosine hA3 receptor, with the Ki of 100 nM.
    MRS1097
  • HY-118461
    PD 120697 108351-91-3 98%
    PD 120697 is an orally active dopamine (DA) agonist. PD 120697 inhibits striatal DA synthesis, DA neuronal firing, spontaneous locomotor activity, and reverses Reserpine (HY-N0480)-induced depression.
    PD 120697
  • HY-118463
    Benzomalvin A 157047-96-6 98%
    Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with Ki values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively.
    Benzomalvin A
  • HY-118482
    Sauristolactam 128533-02-8 98%
    Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation.
    Sauristolactam
  • HY-118489
    L644711 81997-33-3 98%
    L644711 is an anion transport inhibitor that reduces cell swelling by inhibiting potassium-activated D-aspartate release in astrocytes. L644711 can be used in the study of brain injury and neuroprotection.
    L644711
  • HY-118490
    T-2000 97846-21-4 98%
    T-2000 (DMMDPB) is an orally active GABA receptor agonist with anticonvulsant activities.
    T-2000
  • HY-118515
    ATM4 4-Acetoxy analog 91295-74-8 98%
    ATM4 4-Acetoxy analog is an impurity in the synthesis of Heroin.
    ATM4 4-Acetoxy analog
  • HY-118524
    Dipiproverine 117-30-6 98%
    Dipiproverine (LD-935 free base) is an alpha-amino acid ester, an antispasmodic compound, which is used as an anticholinergic agent.
    Dipiproverine
  • HY-118535
    N-Oleoyl valine 60374-41-6 98%
    N-Oleoyl valine is a N-acyl valine compound that acts as a TRPV3 receptor antagonist.
    N-Oleoyl valine
  • HY-118570
    5-Oxoprolyltryptophan 35937-24-7 98%
    5-Oxoprolyltryptophan is a model substrate for investigating the increase of serotonin at the cerebral level.
    5-Oxoprolyltryptophan
  • HY-118574
    UBP141 344768-30-5 98%
    UBP141 is a GluN2C/2D (NR2C/2D)-preferring receptor antagonist, with Kds of 2.8, 4.2, 14.2, and 19.3 μM for NMDA receptor subtypes: GluN2C, 2D, 2A, and 2B, respectively. UBP141 can induce potent motor impairment in WT mice.
    UBP141
  • HY-118575
    DR-4004 201608-41-5 98%
    DR-4004 is a 5-HT7 receptor antagonist that attenuates the decreased level of performance produced by mCPP and the performance levels after p-chloroamphetamine (PCA) lesion of the 5-HT system. DR-4004 also reverses amnesia induced by Scopolamine (HY-N0296) and Dizocilpine (HY-15084B). DR-4004 is promising for research of schizophrenia, cognitive deficits and atypical antipsychotic agents.
    DR-4004
  • HY-118615
    LY2048978 676495-11-7 98%
    LY2048978 is a non-selective opioid receptor antagonist with Ki of 0.287, 0.471 and 1.05 nM for human mu, kappa and delta opioid receptors in vitro, respectively. LY2048978 can be used in the research of major depressive disorder and alcohol use disorder.
    LY2048978
  • HY-118638
    Corynanthine 483-10-3 98%
    Corynanthine is a selective α1-adrenergic receptor antagonist. Corynanthine can significantly lower intraocular pressure in rabbits.
    Corynanthine
  • HY-118656
    Cannabicitran 31508-71-1 98%
    Cannabicitran is a cannabinoid. Cannabicitran can decrease intraocular pressure in rabbits.
    Cannabicitran
  • HY-118657
    Ripazepam 26308-28-1 98%
    Ripazepam (Cl-683) is a potential antianxiety agent. Ripazepam also is a pyrazolodiazepinone derivative and has anxiolytic effects.
    Ripazepam
  • HY-118689
    RA-2 1867107-62-7 98%
    RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation.
    RA-2
  • HY-118710
    α-Isopropylaminopentiophenone hydrochloride 18268-14-9 99.98%
    α-Isopropylaminopentiophenone hydrochloride is a α-aminoketone derivative.
    α-Isopropylaminopentiophenone hydrochloride
  • HY-118727
    6-APDB hydrochloride 1281872-58-9 98%
    6-APDB hydrochloride is a benzofuran.
    6-APDB hydrochloride
  • HY-118768
    FMS586 free base 302556-51-0 98%
    FMS586 free base is a selective neuropeptide Y Y5 receptor antagonist with oral activity. FMS586 can completely block the significant increase in adrenocorticotropic hormone (ACTH) and cortisol caused by the Y(5) selective agonist hPP. FMS586 also reversed the significant upregulation of adrenocorticotropic hormone (CRF) and antidiuretic hormone (AVP) mRNA expression induced by central injection of hPP. FMS586 provides the first evidence that selective stimulation of Y(5) receptors triggers activation of the HPA axis.
    FMS586 free base
Cat. No. Product Name / Synonyms Application Reactivity